Today is May 17, 2006


 

Efficacy of tamarind seed extract against helminths of sheep

  

Ualat et al. (ISU) studied the efficacy of tamarind seed extract against helminths of sheep. Sixty randomly selected sheep, 6-8 months old were used in this study. The different concentrations (100, 75, and 50%) and fractions of the extract were compared with a commercially available dewormer (albendazole). Nonpolar, semipolar, and polar fractions of the test extract were obtained by subjecting the ethanolic extract to solvents of different polarities and concentrated by using the rotavapor. Determination of the LD50 of 50% tamarind seed extract was done by using 60 three-month old mice of both sexes, ICR strain. The completely randomized design (CRD) was used to analyze the data, and least square difference 9LSD) was used to test significant treatment means. The LD50 value was computed by linear regression using Probit transforamtional analysis.

Findings

  • Different concentrations (1100, 75, and 50%) of the tamarind seed extract as well as the semipolar fraction were comparable witht he efficacy of albendazole.
  • Gastrointestinal parasite ova found to be sensitive to the extracts were Oesophagostomum, Trichostrongylus, and Strongyloides.
  • The LD50 was computed to be not more than 16.84 ml/kg. This means that at this level, test extract might be lethal to half of the subject animals.

Source: PCARRD, 2003. Highlights 2002, Los Banos, Laguna

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